| Name | WR 1065 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1232 |
| Prices | $95.00, $349.00 |
| Sizes | 10 mg, 50 mg |
| Cas Number | 14653-77-1 |
| Chemical Name | 2-[(3-Aminopropyl)amino]ethanethioldihydrochloride |
| Formula | C5H14N2S.2HCl |
| Molecular Weight | 207.16 |
| Description | Cell-permeable reactive oxygen species scavenger that activates p53 through a JNK-dependent signaling pathway. Activates p21 waf-1 and MDM2, represses transcription of Myc and thymidine kinase, and inhibits DNA topoisomerase II α . Induces cell cycle arrest and exhibits cytoprotective activity towards normal cells but not cancer cells in vivo . Also exhibits broad spectrum antiviral activity in vitro . |
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North S, El-Ghissassi F, Pluquet O, Verhaegh G, Hainaut P. Oncogene. 2000 Feb 24;19(9):1206-14.
Pluquet O, North S, Bhoumik A, Dimas K, Ronai Z, Hainaut P. J Biol Chem. 2003 Apr 4;278(14):11879-87. Epub 2003 Jan 16.