| Name | WWL 123 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5259 |
| Prices | $189.00, $765.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1338574-83-6 |
| Chemical Name | N-[[1,1'-Biphenyl]-3-ylmethyl)-N-methylcarbamicacid4'-(aminocarbonyl)[1,1'-biphenyl]-4-ylester |
| Formula | C28H24N2O3 |
| Molecular Weight | 436.5 |
| Purity | >98 % |
| Description | α / β -hydrolase domain 6 (ABHD6) inhibitor (IC 50 = 0.43 μ M). Blocks PTZ -induced seizures in healthy mice and spontaneous seizures in R6/2 mice. Antiepileptic activity is independent of CB 1 and CB 2 receptors, but is GABA A receptor dependent. Brain penetrant. |
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Blankman JL, Simon GM, Cravatt BF. Chem Biol. 2007 Dec;14(12):1347-56.
Li W, Blankman JL, Cravatt BF. J Am Chem Soc. 2007 Aug 8;129(31):9594-5. Epub 2007 Jul 13.