Name | WY 14643 |
---|---|
Supplier | Tocris Bioscience |
Catalog | 3252 |
Prices | $59.00, $199.00 |
Sizes | 10 mg, 50 mg |
Function Type | Agonist |
Cas Number | 50892-23-4 |
Chemical Name | [[4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]aceticacid |
Formula | C14H14ClN3O2S |
Molecular Weight | 323.8 |
Purity | >98 % |
Description | Selective PPAR α agonist (EC 50 values are 0.63, 32 and > 100 μ M at PPAR α , PPAR γ and PPAR δ respectively). Negatively inhibits NF- κ B transcriptional activity and decreases the inflammatory response in vitro and in vivo . |
Supplier Page | Shop |
Forman BM, Chen J, Evans RM. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4312-7.
Bishop-Bailey D. Br J Pharmacol. 2000 Mar;129(5):823-34.
Willson TM, Brown PJ, Sternbach DD, Henke BR. J Med Chem. 2000 Feb 24;43(4):527-50.