WY 45233 succinate

• Supplier: Tocris Bioscience
• Catalog: 1312
• Prices: $195.00, $805.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 448904-47-0
• Chemical Name: 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenolsuccinate
• Formula: C16H25NO2.C4H6O4
• Molecular Weight: 381.46
• Purity: >99 %
• Description: Serotonin and noradrenalin reuptake inhibitor (SNRI); selective for human serotonin (SERT) and noradrenalin (NET) transporters against 96 other targets (K i values are 40.2 and 558.4 nM for SERT and NET respectively). Inhibits [ 3 H]5-HT and [ 3 H]NE uptake (IC 50 values are 47.3 and 531.3 nM). Salt form of the major active metabolite of venlafaxine (Cat. No. 2917).

Product References

Pharmacokinetic and pharmacodynamic profiles of the novel serotonin and - Pharmacokinetic and pharmacodynamic profiles of the novel serotonin and

Alfinito PD, Huselton C, Chen X, Deecher DC. Brain Res. 2006 Jul 7;1098(1):71-8. Epub 2006 Jun 9.

Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. - Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor.

Deecher DC, Beyer CE, Johnston G, Bray J, Shah S, Abou-Gharbia M, Andree TH. J Pharmacol Exp Ther. 2006 Aug;318(2):657-65. Epub 2006 May 4.

Desvenlafaxine succinate identifies novel antagonist binding determinants in the - Desvenlafaxine succinate identifies novel antagonist binding determinants in the

Mason JN, Deecher DC, Richmond RL, Stack G, Mahaney PE, Trybulski E, Winneker RC, Blakely RD. J Pharmacol Exp Ther. 2007 Nov;323(2):720-9. Epub 2007 Aug 2.