| Name | WYE 687 dihydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4194 |
| Prices | $255.00, $1,045.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1062161-90-3 |
| Chemical Name | N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-carbamicacidmethylesterhydrochloride |
| Formula | C28H32N8O3 |
| Molecular Weight | 601.53 |
| Purity | >98 % |
| Description | Potent, ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) (IC 50 = 7 nM). Displays selectivity for mTOR over PI 3-K α (~100-fold) and PI 3-K γ (~500-fold). Inhibits phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt; blocks VEGF secretion and HIF-1 α expression. Exhibits antiproliferative effects in cancer cell lines through G 1 cell cycle arrest and selective apoptosis. |
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