WZ 4003

• Supplier: Tocris Bioscience
• Catalog: 4282
• Prices: $195.00, $805.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1214265-58-3
• Chemical Name: N-3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]propanamide
• Formula: C25H29ClN6O3
• Molecular Weight: 496.99
• Purity: >98 %
• Description: Potent and selective NUAK1/2 inhibitor (IC 50 values are 20 and 100 nM respectively). Exhibits no significant inhibition against a panel of 139 kinases, including ten AMPK family members. Inhibits NUAK1-mediated MYPT1 phosphorylation. Also inhibits cell proliferation in U2OS cells.

Product References

Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. - Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.

Zhou W, Ercan D, Chen L, Yun CH, Li D, Capelletti M, Cortot AB, Chirieac L, Iacob RE, Padera R, Engen JR, Wong KK, Eck MJ, Gray NS, Janne PA. Nature. 2009 Dec 24;462(7276):1070-4.

Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1betaMYPT1 - Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1betaMYPT1

Banerjee S, Zagorska A, Deak M, Campbell DG, Prescott AR, Alessi DR. Biochem J. 2014 Jul 15;461(2):233-45.

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the - Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the

Banerjee S, Buhrlage SJ, Huang HT, Deng X, Zhou W, Wang J, Traynor R, Prescott AR, Alessi DR, Gray NS. Biochem J. 2014 Jan 1;457(1):215-25.