XAV 939

• Supplier: Tocris Bioscience
• Catalog: 5248
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 284028-89-3
• Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
• Formula: C14H11F3N2OS
• Molecular Weight: 312.31
• Purity: >98 %
• Description: Potent tankyrase (TNKS) inhibitor (IC 50 values are 4 and 11 nM for TNKS2 and TNKS1 respectively). Antagonizes Wnt signaling via stimulation of β -catenin degradation and stabilization of axin. Inhibits proliferation of the β -catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyogenic development in mesoderm progenitor cells.

Product References

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. - Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.

Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M, Shi X, Wilson CJ, Mickanin C, Myer V, Fazal A, Tomlinson R, Serluca F, Shao W, Cheng H, Shultz M, Rau C, Schirle M, Schlegl J, Ghidelli S, Fawell S, Lu C, Curtis D, Kirschner MW, Lengauer C, Finan PM, Tallarico JA, Bouwmeester T, Porter JA, Bauer A, Cong F. Nature. 2009 Oct 1;461(7264):614-20.

Cardiac induction of embryonic stem cells by a small molecule inhibitor of - Cardiac induction of embryonic stem cells by a small molecule inhibitor of

Wang H, Hao J, Hong CC. ACS Chem Biol. 2011 Feb 18;6(2):192-7.