XE 991 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 5489
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 122955-13-9
• Chemical Name: 10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenonedihydrochloride
• Formula: C26H20N2O.2HCl
• Molecular Weight: 449.37
• Purity: >99 %
• Description: Potent and selective blocker of K V 7 (KCNQ) voltage-gated potassium channels. Blocks K V 7.2+7.3 (KCNQ2+3) / M-currents (IC 50 = 0.6 - 0.98 μ M) and K V 7.1 (KCNQ1) homomeric channels (IC 50 = 0.75 μ M) but is less potent against K V 7.1/minK channels (IC 50 = 11.1 μ M). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo .

Product References

KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the - KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the

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Two new potent neurotransmitter release enhancers, - Two new potent neurotransmitter release enhancers,

Zaczek R, Chorvat RJ, Saye JA, Pierdomenico ME, Maciag CM, Logue AR, Fisher BN, Rominger DH, Earl RA. J Pharmacol Exp Ther. 1998 May;285(2):724-30.

Molecular basis for differential sensitivity of KCNQ and I(Ks) channels to the - Molecular basis for differential sensitivity of KCNQ and I(Ks) channels to the

Wang HS, Brown BS, McKinnon D, Cohen IS. Mol Pharmacol. 2000 Jun;57(6):1218-23.

KCNQ/M currents in sensory neurons: significance for pain therapy. - KCNQ/M currents in sensory neurons: significance for pain therapy.

Passmore GM, Selyanko AA, Mistry M, Al-Qatari M, Marsh SJ, Matthews EA, Dickenson AH, Brown TA, Burbidge SA, Main M, Brown DA. J Neurosci. 2003 Aug 6;23(18):7227-36.