XEN 445

• Supplier: Tocris Bioscience
• Catalog: 2000
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1515856-92-4
• Chemical Name: 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoicacid
• Formula: C18H17F3N2O3
• Molecular Weight: 366.33
• Purity: >98 %
• Description: Selective endothelial lipase (EL) inhibitor (IC 50 = 237 nM for human EL). Exhibits >20-fold selectivity for EL over lipoprotein lipase (LPL) and hepatic lipase (HL). Increases high density lipoprotein cholesterol (HDLc) plasma levels in mice. Orally bioavailable.

Product References

Xenopsin-related peptide generated in avian gastric extracts. - Xenopsin-related peptide generated in avian gastric extracts.

Carraway RE, Cochrane DE, Mitra SP. Regul Pept. 1988 Sep;22(4):303-14.

Metabolism and potency of xenin and of its reduced hexapseudopeptide psi fragment - Metabolism and potency of xenin and of its reduced hexapseudopeptide psi fragment

Feurle GE, Meyer HE, Hamscher G. Life Sci. 2003 Dec 26;74(6):697-707.

Stimulatory effect of xenin-8 on insulin and glucagon secretion in the perfused - Stimulatory effect of xenin-8 on insulin and glucagon secretion in the perfused

Silvestre RA, Rodriguez-Gallardo J, Egido EM, Hernandez R, Marco J. Regul Pept. 2003 Aug 15;115(1):25-9.