| Name | XL 413 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4893 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1169562-71-3 |
| Chemical Name | 8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-onehydrochloride |
| Formula | C14H12ClN3O2.HCl |
| Molecular Weight | 326.18 |
| Purity | >99 % |
| Description | Potent and selective Cdc7 inhibitor (IC 50 = 3.4 nM). Exhibits >12-fold selectivity for Cdc7 over PIM-1 kinase and >30-fold selectivity over pMCM and CK2. Inhibits proliferation of Colo 205 cells in vitro and attenuates tumor growth of Colo 205 xenografts in mice. |
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Koltun ES, Tsuhako AL, Brown DS, Aay N, Arcalas A, Chan V, Du H, Engst S, Ferguson K, Franzini M, Galan A, Holst CR, Huang P, Kane B, Kim MH, Li J, Markby D, Mohan M, Noson K, Plonowski A, Richards SJ, Robertson S, Shaw K, Stott G, Stout TJ, Young J, Yu P, Zaharia CA, Zhang W, Zhou P, Nuss JM, Xu W, Kearney PC. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3727-31.
Sasi NK, Tiwari K, Soon FF, Bonte D, Wang T, Melcher K, Xu HE, Weinreich M. PLoS One. 2014 Nov 20;9(11):e113300.