Y 134

• Supplier: Tocris Bioscience
• Catalog: 4498
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 849662-80-2
• Chemical Name: [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-[4-[4-(1-methylethyl)-1-piperazinyl]phenyl]methanone
• Formula: C28H28N2O3S
• Molecular Weight: 472.6
• Purity: >98 %
• Description: Selective estrogen receptor modulator (SERM) that displays selectivity for ER α over ER β (K i values are 0.09 and 11.31 nM respectively) and no cross-reactivity with mineralocorticoid, glucocorticoid, androgen and progesterone receptors. Acts as an agonist in the bone and antagonist in reproductive tissue. Suppresses estrogen-stimulated proliferation of ER-positive human breast cancer MCF-7 and T47D cells.

Product References

Benzothiophenes containing a piperazine side chain as selective ligands for the - Benzothiophenes containing a piperazine side chain as selective ligands for the

Yang C, Xu G, Li J, Wu X, Liu B, Yan X, Wang M, Xie Y. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1505-7.

Biological activities of a novel selective oestrogen receptor modulator derived - Biological activities of a novel selective oestrogen receptor modulator derived

Ning M, Zhou C, Weng J, Zhang S, Chen D, Yang C, Wang H, Ren J, Zhou L, Jin C, Wang MW. Br J Pharmacol. 2007 Jan;150(1):19-28. Epub 2006 Nov 20.