Y-26763

• Supplier: Tocris Bioscience
• Catalog: 0380
• Prices: $185.00, $755.00
• Sizes: 10 mg, 50 mg
• Cas Number: 127408-31-5
• Chemical Name: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetamide
• Formula: C14H16N2O4
• Molecular Weight: 276.29
• Purity: >98 %
• Description: K ir 6 (K ATP ) channel opener and active metabolite of Y-27152 (Cat. No. 2077). Relaxes contracted rat aortic rings (IC 50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β -cells in vitro . Produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration in vivo .

Product References

Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive - Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive

Nakajima T, Shinohara T, Yaoka O, Fukunari A, Shinagawa K, Aoki K, Katoh A, Yamanaka T, Setoguchi M, Tahara T. J Pharmacol Exp Ther. 1992 May;261(2):730-6.

Y-26763 protects the canine heart from a stunning injury through opening of the - Y-26763 protects the canine heart from a stunning injury through opening of the

Fukunari A, Miyai H, Shinagawa K, Kawahara K, Nakajima T. Eur J Pharmacol. 1997 Apr 4;323(2-3):197-204.

Y-26763: ATP-sensitive K+ channel activation and the inhibition of insulin - Y-26763: ATP-sensitive K+ channel activation and the inhibition of insulin

Cosgrove KE, Straub SG, Barnes PD, Chapman J, Sharp GW, Dunne MJ. Eur J Pharmacol. 2004 Feb 20;486(2):133-9.