Y-27152

• Supplier: Tocris Bioscience
• Catalog: 2076
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Cas Number: 127408-30-4
• Chemical Name: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide
• Formula: C21H22N2O4
• Molecular Weight: 366.41
• Purity: >98 %
• Description: Prodrug of the K ir 6 (K ATP ) channel opener Y-26763 (Cat. No. 2076). Inactive in vitro ; fails to modify tension in contracted aortic rings at concentrations up to 1 mM. Produces long-lasting antihypertensive effects in vivo , with minimal tachycardia following oral administration in hypertensive animals.

Product References

Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive - Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive

Nakajima T, Shinohara T, Yaoka O, Fukunari A, Shinagawa K, Aoki K, Katoh A, Yamanaka T, Setoguchi M, Tahara T. J Pharmacol Exp Ther. 1992 May;261(2):730-6.

Y-26763 protects the canine heart from a stunning injury through opening of the - Y-26763 protects the canine heart from a stunning injury through opening of the

Fukunari A, Miyai H, Shinagawa K, Kawahara K, Nakajima T. Eur J Pharmacol. 1997 Apr 4;323(2-3):197-204.