Y-27632 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2077
• Prices: $109.00, $255.00, $1,045.00
• Sizes: 1 mg, 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 129830-38-2
• Chemical Name: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamidedihydrochloride
• Formula: C14H21N3O.2HCl
• Molecular Weight: 320.26
• Purity: >98 %
• Description: Selective p160ROCK inhibitor (K i values are 0.14, 26, 25 and > 250 μ M for p160ROCK, PKC, PKA and MLCK respectively). Also inhibits PRK2 (IC 50 = 600 nM). Smooth muscle relaxant and orally active in vivo . Increases survival rate of human embryonic stem (hES) cells undergoing cryopreservation. Also optimizes naïve human pluripotent stem cell growth and viability following naïve cell derivation from primed ESCs and iPSCs using naïve human stem cell medium (NHSM).

Product References

Calcium sensitization of smooth muscle mediated by a Rho-associated protein - Calcium sensitization of smooth muscle mediated by a Rho-associated protein

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Use and properties of ROCK-specific inhibitor Y-27632. - Use and properties of ROCK-specific inhibitor Y-27632.

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