Y-29794 oxalate

• Supplier: Tocris Bioscience
• Catalog: 1254
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 146794-84-5
• Chemical Name: [2-[[8-(Dimethylamino)octyl]thio]-6-(1-methylethyl)-3-pyridinyl]-2-thienylmethanoneoxalate
• Formula: C23H34N2OS2.C2H2O4
• Molecular Weight: 508.69
• Purity: >97 %
• Description: Inhibitor of prolyl endopeptidase, a serine peptidase that may be implicated in the biosynthesis of amyloid β -peptide. Potently inhibits rat brain prolyl endopeptidase (K i = 0.95 nM) in vitro , and prevents amyloid β -peptide deposition in vivo . Orally active and brain penetrant.

Product References

Y-29794--a non-peptide prolyl endopeptidase inhibitor that can penetrate into the - Y-29794--a non-peptide prolyl endopeptidase inhibitor that can penetrate into the

Nakajima T, Ono Y, Kato A, Maeda J, Ohe T. Neurosci Lett. 1992 Jul 20;141(2):156-60.

Prevention of amyloid-like deposition by a selective prolyl endopeptidase - Prevention of amyloid-like deposition by a selective prolyl endopeptidase

Kato A, Fukunari A, Sakai Y, Nakajima T. J Pharmacol Exp Ther. 1997 Oct;283(1):328-35.