YC 1

• Supplier: Tocris Bioscience
• Catalog: 1634
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Cas Number: 170632-47-0
• Chemical Name: 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole
• Formula: C19H16N2O2
• Molecular Weight: 304.34
• Purity: >99 %
• Description: Nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of washed rabbit platelets (IC 50 = 14.6 μ M); induces relaxation in denuded phenylephrine-contracted rabbit aortic rings (EC 50 = 1.9 μ M). Also displays antiproliferative activity in vitro and in vivo by inducing G 1 cell cycle arrest in two human hepatocellular carcinoma (HCC) cell lines, and in HCC xenografts in athymic SCID mice. Exhibits low cytotoxicity in non-malignant cells.

Product References

YC-1, a novel activator of platelet guanylate cyclase. - YC-1, a novel activator of platelet guanylate cyclase.

Ko FN, Wu CC, Kuo SC, Lee FY, Teng CM. Blood. 1994 Dec 15;84(12):4226-33.

YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and - YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and

Martin E, Lee YC, Murad F. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12938-42. Epub 2001 Oct 30.

YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] exhibits a novel - YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] exhibits a novel

Wang SW, Pan SL, Guh JH, Chen HL, Huang DM, Chang YL, Kuo SC, Lee FY, Teng CM. J Pharmacol Exp Ther. 2005 Mar;312(3):917-25. Epub 2004 Nov 3.

Molecular mechanisms underlying rat mesenteric artery vasorelaxation induced by - Molecular mechanisms underlying rat mesenteric artery vasorelaxation induced by

Teixeira CE, Priviero FB, Webb RC. J Pharmacol Exp Ther. 2006 Apr;317(1):258-66. Epub 2005 Dec 13.