YIL 781

• Supplier: Tocris Bioscience
• Catalog: 4457
• Prices: $209.00, $879.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 875258-85-8
• Chemical Name: 6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone
• Formula: C24H28FN3O2.HCl
• Molecular Weight: 445.96
• Purity: >98 %
• Description: Ghrelin receptor antagonist (GHS-R1a) (K i = 17 nM). Displays no significant affinity for the motilin receptor (K i = 6 μ M). Blocks the effects of ghrelin on insulin secretion both in vivo and in vitro . Improves glucose homeostasis in vivo .

Product References

Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress - Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress

Esler WP, Rudolph J, Claus TH, Tang W, Barucci N, Brown SE, Bullock W, Daly M, Decarr L, Li Y, Milardo L, Molstad D, Zhu J, Gardell SJ, Livingston JN, Sweet LJ. Endocrinology. 2007 Nov;148(11):5175-85. Epub 2007 Jul 26.

Minireview: Gut peptides: targets for antiobesity drug development? - Minireview: Gut peptides: targets for antiobesity drug development?

Moran TH, Dailey MJ. Endocrinology. 2009 Jun;150(6):2526-30.