YM 022

• Supplier: Tocris Bioscience
• Catalog: 4067
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 145084-28-2
• Chemical Name: (R)-N-[2,3-Dihydro-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)-urea
• Formula: C32H28N4O3
• Molecular Weight: 516.6
• Purity: >99 %
• Description: Extremely potent and highly selective non-peptide CCK 2 silent antagonist (K i values are 68 pM and 63 nM at CCK 2 and CCK 1 receptors respectively). Acts in vivo to potently inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation with a long duration of action.

Product References

Pharmacological profile of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo- - Pharmacological profile of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-

Nishida A, Miyata K, Tsutsumi R, Yuki H, Akuzawa S, Kobayashi A, Kamato T, Ito H, Yamano M, Katuyama Y, et al.. J Pharmacol Exp Ther. 1994 May;269(2):725-31.

Small synthetic ligands of the cholecystokinin-B/gastrin receptor can mimic the - Small synthetic ligands of the cholecystokinin-B/gastrin receptor can mimic the

Beinborn M, Chen C, DeMeo L, McBride EW, Kopin AS. Yale J Biol Med. 1998 May-Aug;71(3-4):337-46.

Long-lasting cholecystokinin(2) receptor blockade after a single subcutaneous - Long-lasting cholecystokinin(2) receptor blockade after a single subcutaneous

Kitano M, Norlen P, Ding XQ, Nakamura S, Hakanson R. Br J Pharmacol. 2000 Jun;130(3):699-705.