YM 202074

• Supplier: Tocris Bioscience
• Catalog: 1408
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 299900-84-8
• Chemical Name: N-Cyclohexyl-6-[[N-(2-methoxyethyl)-N-methylamino]methyl]-N-methylthiazolo[3,2-a]benzoimidazole-2-carboxamidesesquifumarate
• Formula: C22H30N4O2S.1.5C4H4O4
• Molecular Weight: 588.67
• Purity: >99 %
• Description: High affinity, selective metabotropic glutamate receptor type 1 (mGlu 1 ) antagonist. Binds an allosteric site of the rat mGlu 1 receptor with a K i of 4.8 nM. Inhibits mGlu 1 -mediated inositol phosphates production (IC 50 = 8.6 nM in rat cerebellar granule cells). Neuroprotective in vivo .

Product References

Metabotropic glutamate 1 receptor: current concepts and perspectives. - Metabotropic glutamate 1 receptor: current concepts and perspectives.

Ferraguti F, Crepaldi L, Nicoletti F. Pharmacol Rev. 2008 Dec;60(4):536-81.

Neuroprotective effects of the selective type 1 metabotropic glutamate receptor - Neuroprotective effects of the selective type 1 metabotropic glutamate receptor

Kohara A, Takahashi M, Yatsugi S, Tamura S, Shitaka Y, Hayashibe S, Kawabata S, Okada M. Brain Res. 2008 Jan 29;1191:168-79.

Radiosynthesis and evaluation of [11C]YM-202074 as a PET ligand for imaging the - Radiosynthesis and evaluation of [11C]YM-202074 as a PET ligand for imaging the

Yanamoto K, Konno F, Odawara C, Yamasaki T, Kawamura K, Hatori A, Yui J, Wakizaka H, Nengaki N, Takei M, Zhang MR. Nucl Med Biol. 2010 Jul;37(5):615-24.