| Name | YM 230888 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3413 |
| Prices | $189.00, $765.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 446257-23-4 |
| Chemical Name | 4-(Cycloheptylamino)-N-[[(2R)-tetrahydro-2-furanyl]methyl]-thieno[2,3-d]pyrimidine-6-methanamine |
| Formula | C19H28N4OS |
| Molecular Weight | 360.52 |
| Purity | >99 % |
| Description | Selective mGlu 1 antagonist (K i = 13 nM). Inhibits mGlu 1 -mediated inositol phosphate production in rat cerebellar granule cells (IC 50 = 13 nM). Displays antinociceptive and analgesic effects in vitro ; exhibits no significant sedative effect on locomotor activity. |
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Kohara A, Nagakura Y, Kiso T, Toya T, Watabiki T, Tamura S, Shitaka Y, Itahana H, Okada M. Eur J Pharmacol. 2007 Sep 24;571(1):8-16. Epub 2007 Jun 5.
Satow A, Maehara S, Ise S, Hikichi H, Fukushima M, Suzuki G, Kimura T, Tanak T, Ito S, Kawamoto H, Ohta H. J Pharmacol Exp Ther. 2008 Aug;326(2):577-86.