YM 26734

• Supplier: Tocris Bioscience
• Catalog: 4544
• Prices: $189.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 144337-18-8
• Chemical Name: 1,1'-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone
• Formula: C45H62O8
• Molecular Weight: 730.97
• Purity: >95 %
• Description: Competitive inhibitor of secretory phospholipase A 2 (sPLA 2 ) that exhibits a broad inhibitory profile to several sPLA 2 s (IC 50 values are 0.2, 1, 1, 1 and 3 μ M for sPLA 2 -X, -IIA, -IID, -V and -IIE respectively). Displays minimal activity at sPLA 2 -IIF and no activity at cytosolic PLA 2 , cyclooxygenase and lipoxygenase. Ameliorates local inflammatory responses in TPA-induced mouse ear edema.

Product References

Suppression of inflammatory responses to 12-O-tetradecanoyl-phorbol-13-acetate - Suppression of inflammatory responses to 12-O-tetradecanoyl-phorbol-13-acetate

Miyake A, Yamamoto H, Kubota E, Hamaguchi K, Kouda A, Honda K, Kawashima H. Br J Pharmacol. 1993 Sep;110(1):447-53.

Exogenous group II phospholipase A2 induces prostaglandin E2 production in mouse - Exogenous group II phospholipase A2 induces prostaglandin E2 production in mouse

Miyake A, Yamamoto H, Enomori T, Kawashima H. Eur J Pharmacol. 1994 Feb 21;253(1-2):155-61.

Induction of distinct sets of secretory phospholipase A(2) in rodents during - Induction of distinct sets of secretory phospholipase A(2) in rodents during

Hamaguchi K, Kuwata H, Yoshihara K, Masuda S, Shimbara S, Oh-ishi S, Murakami M, Kudo I. Biochim Biophys Acta. 2003 Nov 30;1635(1):37-47.