| Name | YM 298198 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2522 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 1216398-09-2 |
| Chemical Name | 6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamidehydrochloride |
| Formula | C18H22N4OS.HCl |
| Molecular Weight | 378.92 |
| Purity | >99 % |
| Description | Non-competitive antagonist with high affinity and selectivity for mGlu 1 receptors (K i = 19 nM); inactive at other mGlu receptor subtypes (mGlu 2-7 ), ionotropic receptors and glutamate transporters (IC 50 > 10 μ M). Inhibits glutamate-induced IP production more potently than CPCCOEt (IC 50 values are 16 nM and 6.3 μ M respectively), and is orally active in vivo , demonstrating an antinociceptive effect in hyperalgesic mice. Desmethyl derivative (Cat. No. 2447) also available. |
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Kohara A, Toya T, Tamura S, Watabiki T, Nagakura Y, Shitaka Y, Hayashibe S, Kawabata S, Okada M. J Pharmacol Exp Ther. 2005 Oct;315(1):163-9. Epub 2005 Jun 23.
Emery AC, Pshenichkin S, Takoudjou GR, Grajkowska E, Wolfe BB, Wroblewski JT. J Biol Chem. 2010 Aug 20;285(34):26041-8.