YM 511

• Supplier: Tocris Bioscience
• Catalog: 2447
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 148869-05-0
• Chemical Name: 4-[[(4-Bromophenyl)methyl]-4H-1,2,4-triazol-4-ylamino]benzonitrile
• Formula: C16H12BrN5
• Molecular Weight: 354.2
• Purity: >99 %
• Description: Orally active, potent aromatase (CYP19) inhibitor (IC 50 values are 0.4 and 0.12 nM at rat ovary and human placenta cells respectively) that only weakly inhibits the synthesis of other steroid hormones. Reduces plasma estrogen levels into ranges induced by ovariectomy and inhibits testosterone-induced breast cancer cell growth in vitro (IC 50 = 0.13 nM).

Product References

Studies on aromatase inhibitors. I. Synthesis and biological evaluation of - Studies on aromatase inhibitors. I. Synthesis and biological evaluation of

Okada M, Yoden T, Kawaminami E, Shimada Y, Kudoh M, Isomura Y, Shikama H, Fujikura T. Chem Pharm Bull (Tokyo). 1996 Oct;44(10):1871-9.