| Name | YM 58483 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3278 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Blocker |
| Cas Number | 223499-30-7 |
| Chemical Name | N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide |
| Formula | C15H9F6N5OS |
| Molecular Weight | 421.32 |
| Purity | >99 % |
| Description | Blocker of store-operated Ca 2+ entry (SOCE), which mediates the activation of non-excitable cells (e.g. lymphocytes). Inhibits calcium release-activated calcium (CRAC) channels; suppresses thapsigargin-induced sustained Ca 2+ influx (IC 50 = 100 nM). Displays immuno-modulatory and anti-inflammatory effects; suppresses cytokine production and proliferation of T cells in vitro . |
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