YM 90709

• Supplier: Tocris Bioscience
• Catalog: 3039
• Prices: $205.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 163769-88-8
• Chemical Name: 5,6-Dihydro-2,3-dimethoxy-6,6-dimethylbenz[7,8]indolizino[2,3-b]quinoxaline
• Formula: C22H21N3O2
• Molecular Weight: 359.43
• Purity: >99 %
• Description: Novel, selective inhibitor of interleukin-5 (IL-5) (IC 50 = 0.45 - 1 mM). Inhibits IL-5-prolonged eosinophil survival and IL-5-induced tyrosine phosphorylation of JAK2 without inhibiting GM-CSF-mediated effects. Inhibits antigen-induced eosinophil and lymphocyte recruitment in rat airways in vivo , without affecting peripheral blood or bone marrow leukocytes.

Product References

Characterization of YM-90709 as a novel antagonist which inhibits the binding of - Characterization of YM-90709 as a novel antagonist which inhibits the binding of

Morokata T, Ida K, Yamada T. Int Immunopharmacol. 2002 Nov;2(12):1693-702.

Effect of a novel interleukin-5 receptor antagonist, YM-90709 - Effect of a novel interleukin-5 receptor antagonist, YM-90709

Morokata T, Suzuki K, Ida K, Tsuchiyama H, Ishikawa J, Yamada T. Int Immunopharmacol. 2004 Jul;4(7):873-83.

Effect of a novel interleukin-5 receptor antagonist, YM-90709, on antigen-induced - Effect of a novel interleukin-5 receptor antagonist, YM-90709, on antigen-induced

Morokata T, Suzuki K, Ida K, Yamada T. Immunol Lett. 2005 Apr 15;98(1):161-5. Epub 2004 Nov 28.