YM 90K hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1675
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 154164-30-4
• Chemical Name: 1,4-Dihydro-6-(1H-imidazol-1-yl)-7-nitro-2,3-quinoxalinedionehydrochloride
• Formula: C11H7N5O4.HCl
• Molecular Weight: 309.67
• Purity: >99 %
• Description: Selective AMPA receptor antagonist (K i values are 84, 2200 and > 37000 nM for AMPA, kainate and NMDA receptors respectively). Neuroprotective; delays neuronal death in a global ischemia model and cerebral infarction in a focal ischemia model following postischemic administration.

Product References

6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) - 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K)

Ohmori J, Sakamoto S, Kubota H, Shimizu-Sasamata M, Okada M, Kawasaki S, Hidaka K, Togami J, Furuya T, Murase K. J Med Chem. 1994 Feb 18;37(4):467-75.

Neuroprotective effect of a novel AMPA receptor antagonist, YM90K, in rat focal - Neuroprotective effect of a novel AMPA receptor antagonist, YM90K, in rat focal

Umemura K, Shimakura A, Nakashima M. Brain Res. 1997 Oct 31;773(1-2):61-5.

A potent AMPA/kainate receptor antagonist, YM90K, attenuates the loss of - A potent AMPA/kainate receptor antagonist, YM90K, attenuates the loss of

Nakano M, Ueda H, Li JY, Matsumoto M, Yanagihara T. Life Sci. 2001 Sep 14;69(17):1983-90.