Zamifenacin fumarate

• Supplier: Tocris Bioscience
• Catalog: 3655
• Prices: $185.00, $755.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 127308-98-9
• Chemical Name: (3R)-1-[2-(1-,3-Benzodioxol-5-yl)ethyl]-3-(diphenylmethoxy)piperidinefumarate
• Formula: C27H29NO3.C4H4O4
• Molecular Weight: 531.6
• Purity: >99 %
• Description: Selective M 3 muscarinic receptor antagonist (pK i values are 8.52, 7.93, 7.90 and 7.78 for M 3 , M 2 , M 1 and M 4 receptors respectively). Displays higher affinity at ileal M 3 receptors (pK i = 9.3) compared to oesophageal and tracheal M 3 receptors (pK i values are 8.8 and 8.2 respectively). Inhibits gastrointestinal motility in vivo in the absence of cardiovascular effects.

Product References

Pre-clinical and clinical pharmacology of selective muscarinic M3 receptor - Pre-clinical and clinical pharmacology of selective muscarinic M3 receptor

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Characterization of the interaction of zamifenacin at muscarinic receptors in - Characterization of the interaction of zamifenacin at muscarinic receptors in

Watson N, Reddy H, Stefanich E, Eglen RM. Eur J Pharmacol. 1995 Oct 16;285(2):135-42.

Muscarinic receptors in isolated urinary bladder smooth muscle from different - Muscarinic receptors in isolated urinary bladder smooth muscle from different

Choppin A. Br J Pharmacol. 2002 Oct;137(4):522-8.