Zaprinast

Name Zaprinast
Supplier Tocris Bioscience
Catalog 0180
Prices $75.00
Sizes 25 mg
Function Type Inhibitor
Cas Number 37762-06-4
Chemical Name 2-(2-Propyloxyphenyl)-8-azapurin-6-one
Formula C13H13N5O2
Molecular Weight 271.28
Purity >99 %
Description Phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC 50 values are 0.15, 0.76, 12.0 and 29.0 μ M respectively). Putative GPR35 agonist.
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Product References

Identification and characterization of a novel family of cyclic nucleotide - Identification and characterization of a novel family of cyclic nucleotide

Soderling SH, Bayuga SJ, Beavo JA. J Biol Chem. 1998 Jun 19;273(25):15553-8.

Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the - Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the

Lugnier C. Pharmacol Ther. 2006 Mar;109(3):366-98. Epub 2005 Aug 15.

Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase - Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase

Taniguchi Y, Tonai-Kachi H, Shinjo K. FEBS Lett. 2006 Sep 18;580(21):5003-8. Epub 2006 Aug 17.