Zatebradine hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1046
• Prices: $155.00, $645.00
• Sizes: 10 mg, 50 mg
• Cas Number: 91940-87-3
• Chemical Name: 3-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-onehydrochloride
• Formula: C26H36N2O5.HCl
• Molecular Weight: 493.04
• Purity: >98 %
• Description: Bradycardic agent that produces use-dependent inhibition of hyperpolarization-activated current I f (HCN channel) in sinoatrial node cells (EC 50 = 480 nM) and Purkinje fibres. Displays negative chronotropic activity in isolated guinea pig atria (EC 50 of 13.4 μ M).

Product References

Use- and frequency-dependent blockade by UL-FS 49 of the if pacemaker current in - Use- and frequency-dependent blockade by UL-FS 49 of the if pacemaker current in

Van Bogaert PP, Goethals M, Simoens C. Eur J Pharmacol. 1990 Oct 9;187(2):241-56.

Use-dependent block of the pacemaker current I(f) in rabbit sinoatrial node cells - Use-dependent block of the pacemaker current I(f) in rabbit sinoatrial node cells

Goethals M, Raes A, van Bogaert PP. Circulation. 1993 Nov;88(5 Pt 1):2389-401.

Design, synthesis and preliminary biological evaluation of zatebradine analogues - Design, synthesis and preliminary biological evaluation of zatebradine analogues

Romanelli MN, Cerbai E, Dei S, Guandalini L, Martelli C, Martini E, Scapecchi S, Teodori E, Mugelli A. Bioorg Med Chem. 2005 Feb 15;13(4):1211-20.