Z -Cyclopentyl-AP4

• Supplier: Tocris Bioscience
• Catalog: 4794
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 103439-17-4
• Chemical Name: cis-(±)-1-Amino-3-phosphonocyclopentanecarboxylicacid
• Formula: C6H12NO5P
• Molecular Weight: 209.14
• Purity: >98 %
• Description: Group III mGlu receptor agonist that exhibits higher potency at mGlu 4 than mGlu 8 (EC 50 values are 49 and 124 μ M respectively) with no activity at mGlu 7 . Selectively inhibits synaptic activity in the lateral perforant pathway (IC 50 values are 130 and 1859 μ M in the lateral and medial perforant pathways respectively). Conformationally restrained analog of L-AP4 (Cat No. 0103).

Product References

Cyclic analogues of 2-amino-4-phosphonobutanoic acid (APB) and their inhibition - Cyclic analogues of 2-amino-4-phosphonobutanoic acid (APB) and their inhibition

Crooks SL, Robinson MB, Koerner JF, Johnson RL. J Med Chem. 1986 Oct;29(10):1988-95.

Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is - Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is

Ayala JE, Niswender CM, Luo Q, Banko JL, Conn PJ. Neuropharmacology. 2008 Apr;54(5):804-14.

Metabotropic glutamate receptors mGluR4 and mGluR8 regulate transmission in the - Metabotropic glutamate receptors mGluR4 and mGluR8 regulate transmission in the

Jones PJ, Xiang Z, Conn PJ. Neuropharmacology. 2008 Sep;55(4):440-6.