ZD 7288

• Supplier: Tocris Bioscience
• Catalog: 1211
• Prices: $155.00, $645.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 133059-99-1
• Chemical Name: 4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidiniumchloride
• Formula: C15H21ClN4
• Molecular Weight: 292.81
• Purity: >99 %
• Description: Sino-atrial node function modulator; blocks the hyperpolarization activated cation current I f (HCN channel). Blocks I h in central neurons. Increases NMDA-evoked noradrenalin release in rat brain in vitro .

Product References

Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated - Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated

BoSmith RE, Briggs I, Sturgess NC. Br J Pharmacol. 1993 Sep;110(1):343-9.

Mechanism of block by ZD 7288 of the hyperpolarization-activated inward - Mechanism of block by ZD 7288 of the hyperpolarization-activated inward

Harris NC, Constanti A. J Neurophysiol. 1995 Dec;74(6):2366-78.

Pharmacological characterization of the inwardly-rectifying current in the smooth - Pharmacological characterization of the inwardly-rectifying current in the smooth

Green ME, Edwards G, Kirkup AJ, Miller M, Weston AH. Br J Pharmacol. 1996 Dec;119(8):1509-18.

Ih channels as modulators of presynaptic terminal function: ZD7288 increases - Ih channels as modulators of presynaptic terminal function: ZD7288 increases

Klar M, Surges R, Feuerstein TJ. Naunyn Schmiedebergs Arch Pharmacol. 2003 Apr;367(4):422-5. Epub 2003 Mar 13.