Zebularine

• Supplier: Tocris Bioscience
• Catalog: 3975
• Prices: $139.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 3690-10-6
• Chemical Name: 1-β-D-Ribofuranosyl-2(1H)-pyrimidinone
• Formula: C9H12N2O5
• Molecular Weight: 228.2
• Purity: >99 %
• Description: Orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC 50 = 120 μ M) and re-activates silenced genes in T24 bladder carcinoma cells. Inhibits cytidine deaminase (K i ~ 2 μ M); induces differentiation of mesenchymal stem cells into cardiomyocytes.

Product References

Potent inhibitors for the deamination of cytosine arabinoside and - Potent inhibitors for the deamination of cytosine arabinoside and

Laliberte J, Marquez VE, Momparler RL. Cancer Chemother Pharmacol. 1992;30(1):7-11.

Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human - Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human

Ben-Kasus T, Ben-Zvi Z, Marquez VE, Kelley JA, Agbaria R. Biochem Pharmacol. 2005 Jul 1;70(1):121-33.