Zimelidine dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3308
• Prices: $75.00, $315.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 60525-15-7
• Chemical Name: (2Z)-3-(4-Bromophenyl)-N,N-dimethyl-3-(3-pyrindinyl)-2-propen-1-aminedihydrochloride
• Formula: C16H17BrN2.2HCl
• Molecular Weight: 390.15
• Purity: >98 %
• Description: 5-HT re-uptake inhibitor; selective over noradrenalin and dopamine uptake (IC 50 values are 0.33, 8.2 and 12 μ M respectively). Modulates nociception and induces hyperglycemia in vivo , and is an orally active antidepressant.

Product References

The pharmacology of zimelidine: a 5-HT selective reuptake inhibitor. - The pharmacology of zimelidine: a 5-HT selective reuptake inhibitor.

Ogren SO, Ross SB, Hall H, Holm AC, Renyi AL. Acta Psychiatr Scand Suppl. 1981;290:127-51.

Changes in nociception after acute and chronic administration of zimelidine: - Changes in nociception after acute and chronic administration of zimelidine:

Fasmer OB, Post C, Hole K. Neuropharmacology. 1987 Apr;26(4):309-12.

Involvement of serotonin in zimelidine-induced hyperglycemia in mice. - Involvement of serotonin in zimelidine-induced hyperglycemia in mice.

Sugimoto Y, Inoue K, Yamada J. Biol Pharm Bull. 1999 Nov;22(11):1240-1.