ZIP

Name ZIP
Supplier Tocris Bioscience
Catalog 1051
Prices $199.00
Sizes 1 mg
Function Type Inhibitor
Cas Number 863987-12-6
Formula C90H154N30O17
Molecular Weight 1982.4
Description Novel, cell-permeable inhibitor of protein kinase M ζ (PKM ζ ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKM ζ -induced synaptic potentiation in hippocampal slices in vitro . Reverses late-phase LTP (IC 50 = 1 - 2.5 μ M) and produces persistent loss of 1-day-old spatial memory following central administration in vivo . Control and biotinylated peptides (Cat. Nos. 3215 and 3290) also available.
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Product References

Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term - Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term

Serrano P, Yao Y, Sacktor TC. J Neurosci. 2005 Feb 23;25(8):1979-84.

Storage of spatial information by the maintenance mechanism of LTP. - Storage of spatial information by the maintenance mechanism of LTP.

Pastalkova E, Serrano P, Pinkhasova D, Wallace E, Fenton AA, Sacktor TC. Science. 2006 Aug 25;313(5790):1141-4.