Ziprasidone hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3290
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Cas Number: 138982-67-9
• Chemical Name: 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-onehydrochloride
• Formula: C21H21ClN4OS.HCl
• Molecular Weight: 449.4
• Purity: >99 %
• Description: Atypical antipsychotic that displays combined serotonin and dopamine receptor antagonism. Displays high affinity at 5-HT 2A receptors with a 5-HT 2A /D 2 affinity ratio greater than any other clinically available atypical antipsychotics (pK i values are 9.38, 8.88, 8.69, 8.47, 8.32, 8.14, 7.98, 7.49, 7.33 and 6.28 for 5-HT 2A , 5-HT 2C , 5-HT 1D , 5-HT 1A , D 2 , D 3 , α 1 , D 4 , H 1 and D 1 receptors respectively).

Product References

Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin - Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin

Seeger TF, Seymour PA, Schmidt AW, Zorn SH, Schulz DW, Lebel LA, McLean S, Guanowsky V, Howard HR, Lowe JA 3rd, et al.. J Pharmacol Exp Ther. 1995 Oct;275(1):101-13.

Ziprasidone: a novel antipsychotic agent with a unique human receptor binding - Ziprasidone: a novel antipsychotic agent with a unique human receptor binding

Schmidt AW, Lebel LA, Howard HR Jr, Zorn SH. Eur J Pharmacol. 2001 Aug 17;425(3):197-201.

Investigation into the effects of the novel antipsychotic ziprasidone on weight - Investigation into the effects of the novel antipsychotic ziprasidone on weight

Fell MJ, Gibson R, McDermott E, Sisodia G, Marshall KM, Neill JC. Behav Brain Res. 2005 May 28;160(2):338-43. Epub 2005 Jan 17.