| Name | ZK 93423 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2565 |
| Prices | $175.00, $709.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Agonist |
| Cas Number | 1216574-52-5 |
| Chemical Name | 4-(Methoxymethyl)-6-(phenylmethoxy)-9H-pyrido[3,4-b]indole-3-carboxylicacidethylesterhydrochloride |
| Formula | C23H22N2O4.HCl |
| Molecular Weight | 426.9 |
| Purity | >98 % |
| Description | Potent benzodiazepine receptor agonist (IC 50 = 1 nM). Non-selective between α 1-, α 2-, α 3- and α 5-subunit containing GABA A receptors (K i values are 4.1, 4.2, 6 and 4.5 nM for inhibition of [ 3 H]Ro15-1788 binding to human recombinant α 1 β 3 γ 2, α 2 β 3 γ 2, α 3 β 3 γ 2 and α 5 β 3 γ 2 receptors respectively). Anxiolytic following systemic administration in vivo . |
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Cox ED, Diaz-Arauzo H, Huang Q, Reddy MS, Ma C, Harris B, McKernan R, Skolnick P, Cook JM. J Med Chem. 1998 Jul 2;41(14):2537-52.