ZK 93426 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1994
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1216792-30-1
• Chemical Name: 4-Methyl-5-(1-methylethoxy)-9H-pyrido[3,4-b]indole-3-carboxylicacidethylesterhydrochloride
• Formula: C18H20N2O3.HCl
• Molecular Weight: 348.82
• Purity: >99 %
• Description: Potent, selective and competitive benzodiazepine receptor antagonist (IC 50 values are 0.4 and 0.7 nM for inhibition of [ 3 H]-flunitrazepam binding to rat cerebellum and hippocampus respectively). Similar in vivo profile to flumazenil (Ro 15-1788, Cat No. 1328); produces anxiogenic effects in some behavioral tests and anxiolytic effects in others. Orally active.

Product References

Evaluation of the beta-carboline ZK 93 426 as a benzodiazepine receptor - Evaluation of the beta-carboline ZK 93 426 as a benzodiazepine receptor

Jensen LH, Petersen EN, Braestrup C, Honore T, Kehr W, Stephens DN, Schneider H, Seidelmann D, Schmiechen R. Psychopharmacology (Berl). 1984;83(3):249-56.

Enhancement of gamma-aminobutyric acid binding by the anxiolytic beta-carbolines - Enhancement of gamma-aminobutyric acid binding by the anxiolytic beta-carbolines

Corda MG, Giorgi O, Longoni B, Mereu GP, Biggio G. J Neurochem. 1987 May;48(5):1355-8.

Effects of beta-carbolines in animal models of anxiety. - Effects of beta-carbolines in animal models of anxiety.

File SE, Baldwin HA. Brain Res Bull. 1987 Sep;19(3):293-9.