ZLN 024 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1996
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Chemical Name: 2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]pyrimidinehydrochloride
• Formula: C13H13BrN2OS.HCl
• Molecular Weight: 361.69
• Purity: >99 %
• Description: Allosteric AMP-activated protein kinase (AMPK) activator; allosterically stimulates active AMPK heterotrimers, increasing the activity of α 1 β 1 γ 1 by 1.5-fold and α 2 β 1 γ 1 by 1.7-fold (EC 50 values are 0.42 and 0.95 μ M, respectively). Inhibits dephosphorylation of AMPK Thr-172 by PP2C α . Stimulates glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio. Also decreases fatty acid synthesis and glucose output in primary hepatocytes. Improves glucose tolerance and decreases cholesterol content in db/db mice.

Product References

Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic - Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic

Li YY, Yu LF, Zhang LN, Qiu BY, Su MB, Wu F, Chen DK, Pang T, Gu M, Zhang W, Ma WP, Jiang HW, Li JY, Nan FJ, Li J. Toxicol Appl Pharmacol. 2013 Dec 1;273(2):325-34. doi:

Novel small-molecule AMP-activated protein kinase allosteric activator with - Novel small-molecule AMP-activated protein kinase allosteric activator with

Zhang LN, Xu L, Zhou HY, Wu LY, Li YY, Pang T, Xia CM, Qiu BY, Gu M, Dong TC, Li JY, Shen JK, Li J. PLoS One. 2013 Aug 20;8(8):e72092.