| Name | ZM 323881 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2499 |
| Prices | $115.00, $249.00 |
| Sizes | 1 mg, 10 mg |
| Function Type | Inhibitor |
| Cas Number | 193000-39-4 |
| Chemical Name | 5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methylphenolhydrochloride |
| Formula | C22H18FN3O2.HCl |
| Molecular Weight | 411.86 |
| Purity | >99 % |
| Description | Potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) activity. Selectively inhibits VEGFR-2 (IC 50 = 2 nM) over VEGFR-1 and a range of other receptor tyrosine kinases such as PDGFR β , FGFR1, EGFR and erbB2 (IC 50 > 50 μ M). Inhibits VEGF-A-induced endothelial cell proliferation in vitro (IC 50 = 8 nM). |
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Whittles CE, Pocock TM, Wedge SR, Kendrew J, Hennequin LF, Harper SJ, Bates DO. Microcirculation. 2002 Dec;9(6):513-22.
Endo A, Fukuhara S, Masuda M, Ohmori T, Mochizuki N. J Recept Signal Transduct Res. 2003;23(2-3):239-54.