| Name | ZM 336372 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2475 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 208260-29-1 |
| Chemical Name | 3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)-amino]-4-methylphenyl]benzamide |
| Formula | C23H23N3O3 |
| Molecular Weight | 389.45 |
| Purity | >99 % |
| Description | Potent, selective inhibitor of c-Raf in vitro (IC 50 = 70 nM for inhibition of human c-Raf). Shows 10-fold selectivity over B-Raf. Also inhibits SAPK2/p38 (IC 50 = 2 μ M). Selective over 17 other protein kinases including PKA, PKC, p42 MAPK, CDK1 and SAPK1/JNK (up to 50 μ M). Also available as part of the MAPK Cascade Inhibitor Tocriset™ . |
| Supplier Page | Shop |
Hall-Jackson CA, Eyers PA, Cohen P, Goedert M, Boyle FT, Hewitt N, Plant H, Hedge P. Chem Biol. 1999 Aug;6(8):559-68.
Wartenberg M, Ling FC, Schallenberg M, Baumer AT, Petrat K, Hescheler J, Sauer H. J Biol Chem. 2001 May 18;276(20):17420-8. Epub 2001 Feb 20.