ZM 447439

Name	ZM 447439
Supplier	Tocris Bioscience
Catalog	1367
Prices	$245.00
Sizes	10 mg
Function Type	Inhibitor
Cas Number	331771-20-1
Chemical Name	N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
Formula	C29H31N5O4
Molecular Weight	513.59
Purity	>98 %
Description	Novel, selective ATP-competitive inhibitor of Aurora B kinase in vitro (IC 50 values are 50, 250 and 1000 nM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC 50 > 10 μ M). Inhibits cell division and displays selective toxicity towards proliferating tumor cells versus non-dividing cells.
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Product References

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and - Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and

Ditchfield C, Johnson VL, Tighe A, Ellston R, Haworth C, Johnson T, Mortlock A, Keen N, Taylor SS. J Cell Biol. 2003 Apr 28;161(2):267-80.

Validating Aurora B as an anti-cancer drug target. - Validating Aurora B as an anti-cancer drug target.

Girdler F, Gascoigne KE, Eyers PA, Hartmuth S, Crafter C, Foote KM, Keen NJ, Taylor SS. J Cell Sci. 2006 Sep 1;119(Pt 17):3664-75. Epub 2006 Aug 15.

Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B - Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B

Jung FH, Pasquet G, Lambert-van der Brempt C, Lohmann JJ, Warin N, Renaud F, Germain H, De Savi C, Roberts N, Johnson T, Dousson C, Hill GB, Mortlock AA, Heron N, Wilkinson RW, Wedge SR, Heaton SP, Odedra R, Keen NJ, Green S, Brown E, Thompson K, Brightwell S. J Med Chem. 2006 Feb 9;49(3):955-70.