| Name | ZM 449829 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2458 |
| Prices | $139.00, $585.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 4452-06-6 |
| Chemical Name | 1-(2-Naphthalenyl)-2-propen-1-one |
| Formula | C13H10O |
| Molecular Weight | 182.22 |
| Purity | >98 % |
| Description | Potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3) which binds competitively to the JAK3 ATP site. pIC 50 values are 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Inhibits STAT-5 phosphorylation and T cell proliferation. |
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Orange JS, Roy-Ghanta S, Mace EM, Maru S, Rak GD, Sanborn KB, Fasth A, Saltzman R, Paisley A, Monaco-Shawver L, Banerjee PP, Pandey R. J Clin Invest. 2011 Apr;121(4):1535-48.