Zolpidem

• Supplier: Tocris Bioscience
• Catalog: 4657
• Prices: $165.00, $685.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 82626-48-0
• Chemical Name: N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide
• Formula: C19H21N3O
• Molecular Weight: 307.39
• Purity: >99 %
• Description: Benzodiazepine agonist with high selectivity for α 1-subunit-containing GABA A receptors (BZ/ ω 1 site) and very high intrinsic activity. K i values are 20, 400 and ≥ 5000 nM for α 1-, α 2-/ α 3-, and α 5-containing GABA A receptors respectively. Hypnotic that does not induce physical dependence.

Product References

High affinity [3H]zolpidem binding in the rat brain: an imidazopyridine with - High affinity [3H]zolpidem binding in the rat brain: an imidazopyridine with

Arbilla S, Allen J, Wick A, Langer SZ. Eur J Pharmacol. 1986 Nov 4;130(3):257-63.

Zolpidem, a novel nonbenzodiazepine hypnotic. I. Neuropharmacological and - Zolpidem, a novel nonbenzodiazepine hypnotic. I. Neuropharmacological and

Depoortere H, Zivkovic B, Lloyd KG, Sanger DJ, Perrault G, Langer SZ, Bartholini G. J Pharmacol Exp Ther. 1986 May;237(2):649-58.

Lack of tolerance and physical dependence upon repeated treatment with the novel - Lack of tolerance and physical dependence upon repeated treatment with the novel

Perrault G, Morel E, Sanger DJ, Zivkovic B. J Pharmacol Exp Ther. 1992 Oct;263(1):298-303.

Mechanism of action of the hypnotic zolpidem in vivo. - Mechanism of action of the hypnotic zolpidem in vivo.

Crestani F, Martin JR, Mohler H, Rudolph U. Br J Pharmacol. 2000 Dec;131(7):1251-4.