Zoniporide dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 0655
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 241799-10-0
• Chemical Name: [1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidinedihydrochloride
• Formula: C17H16N6O.2HCl
• Molecular Weight: 393.27
• Purity: >99 %
• Description: Sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor that displays selectivity over other NHE isoforms (K i values are 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3 respectively). Inhibits NHE1 dependent 22 Na + uptake in vitro (IC 50 = 14 nM) and provides cardioprotection from myocardial ischemic injury in vivo (EC 50 = 0.25 nM). Also inhibits MMP2/9 activity and invasion in breast cancer cells.

Product References

A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces - A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces

Knight DR, Smith AH, Flynn DM, MacAndrew JT, Ellery SS, Kong JX, Marala RB, Wester RT, Guzman-Perez A, Hill RJ, Magee WP, Tracey WR. J Pharmacol Exp Ther. 2001 Apr;297(1):254-9.

Zoniporide: a potent and highly selective inhibitor of human Na(+)/H(+) - Zoniporide: a potent and highly selective inhibitor of human Na(+)/H(+)

Marala RB, Brown JA, Kong JX, Tracey WR, Knight DR, Wester RT, Sun D, Kennedy SP, Hamanaka ES, Ruggeri RB, Hill RJ. Eur J Pharmacol. 2002 Sep 6;451(1):37-41.

Cardioprotective efficacy of zoniporide, a potent and selective inhibitor of - Cardioprotective efficacy of zoniporide, a potent and selective inhibitor of

Clements-Jewery H, Sutherland FJ, Allen MC, Tracey WR, Avkiran M. Br J Pharmacol. 2004 May;142(1):57-66. Epub 2004 Mar 22.