Zonisamide

• Supplier: Tocris Bioscience
• Catalog: 2727
• Prices: $99.00, $419.00
• Sizes: 10 mg, 50 mg
• Cas Number: 68291-97-4
• Chemical Name: 1,2-Benzisoxazole-3-methanesulfonamide
• Formula: C8H8N2O3S
• Molecular Weight: 212.22
• Purity: >99 %
• Description: Antiepileptic that possesses a broad spectrum anticonvulsant and mechanistic profile. Blocks voltage-sensitive Na + and T-type Ca 2+ channels, stimulates BK Ca channels, modulates GABA, glutamate and monoamine neurotransmission, inhibits lipid peroxidation and scavenges hydroxyl and nitric oxide free radicals. Displays neuroprotective and antiParkinsonian activity.

Product References

In vivo evaluation of hippocampal anti-oxidant ability of zonisamide in rats. - In vivo evaluation of hippocampal anti-oxidant ability of zonisamide in rats.

Tokumaru J, Ueda Y, Yokoyama H, Nakajima A, Doi T, Mitsuyama Y, Ohya-Nishiguchi H, Kamada H. Neurochem Res. 2000 Aug;25(8):1107-11.

Zonisamide: a new antiepileptic drug. - Zonisamide: a new antiepileptic drug.

Sobieszek G, Borowicz KK, Kimber-Trojnar Z, Malek R, Piskorska B, Czuczwar SJ. Pol J Pharmacol. 2003 Sep-Oct;55(5):683-9.

Novel dopamine releasing response of an anti-convulsant agent with possible - Novel dopamine releasing response of an anti-convulsant agent with possible

Gluck MR, Santana LA, Granson H, Yahr MD. J Neural Transm. 2004 Jun;111(6):713-24. Epub 2004 Apr 8.

Activation by zonisamide, a newer antiepileptic drug, of large-conductance - Activation by zonisamide, a newer antiepileptic drug, of large-conductance

Huang CW, Huang CC, Wu SN. J Pharmacol Exp Ther. 2007 Apr;321(1):98-106. Epub 2007 Jan 25.