Zosuquidar trihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1094
• Prices: $185.00, $755.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 167465-36-3
• Chemical Name: (αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanoltrihydrochloride
• Formula: C32H31F2N3O2.3HCl
• Molecular Weight: 636.99
• Purity: >98 %
• Description: High affinity P-glycoprotein (P-gp) inhibitor (K d = 79 nM). Restores doxorubicin (Cat. No. 2252) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines. Also potentiates antitumor efficacy of taxol (Cat. No. 1097) in a MDR human non-small cell lung carcinoma xenograft mouse model.

Product References

Reversal of P-glycoprotein-mediated multidrug resistance by a potent - Reversal of P-glycoprotein-mediated multidrug resistance by a potent

Dantzig AH, Shepard RL, Cao J, Law KL, Ehlhardt WJ, Baughman TM, Bumol TF, Starling JJ. Cancer Res. 1996 Sep 15;56(18):4171-9.

Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein - Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein

Dantzig AH, Shepard RL, Law KL, Tabas L, Pratt S, Gillespie JS, Binkley SN, Kuhfeld MT, Starling JJ, Wrighton SA. J Pharmacol Exp Ther. 1999 Aug;290(2):854-62.