Zotepine

• Supplier: Tocris Bioscience
• Catalog: 5456
• Prices: $89.00, $375.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 26615-21-4
• Chemical Name: 2-[(8-Chlorodibenzo(Z)[b,f]thiepin-10-yl)oxy]-N,N-dimethylethanamine
• Formula: C18H18ClNOS
• Molecular Weight: 331.86
• Purity: >99 %
• Description: 5-HT 2A receptor and dopamine D 2 receptor antagonist (K i values are 0.69 and 2.3 nM respectively). Also a potent histamine H 1 receptor antagonist (IC 50 = 8.0 nM). Atypical antipsychotic; exhibits antidepressive and anxiolytic effects in vivo .

Product References

Inverse agonist activity of atypical antipsychotic drugs at human - Inverse agonist activity of atypical antipsychotic drugs at human

Herrick-Davis K, Grinde E, Teitler M. J Pharmacol Exp Ther. 2000 Oct;295(1):226-32.

Effects of zotepine on extracellular levels of monoamine, GABA and glutamate in - Effects of zotepine on extracellular levels of monoamine, GABA and glutamate in

Yamamura S, Ohoyama K, Hamaguchi T, Nakagawa M, Suzuki D, Matsumoto T, Motomura E, Tanii H, Shiroyama T, Okada M. Br J Pharmacol. 2009 Jun;157(4):656-65.

Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like - Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like

Shobo M, Kondo Y, Yamada H, Mihara T, Yamamoto N, Katsuoka M, Harada K, Ni K, Matsuoka N. J Pharmacol Exp Ther. 2010 Jun;333(3):772-81.