| Description |
NAE Inhibitor contains the active component of MLN4924, a cell-permeable, small molecule inhibitor of Nedd8 activating enzyme (NAE). By inhibiting the Neddylation pathway this molecule disrupts cullin-RING ligase activity, leading to inhibition of proliferation or apoptotic death of various human tumor cells through the deregulation of S-phase DNA synthesis. Mutations in UBA3, a gene encoding one of the subunits of Nedd8 activating enzyme, have been reported to cause resistance to MLN4924 in some tumor cell lines.
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