proTAME - E3 Ligase, APC/C

• Supplier: Boston Biochem
• Catalog: I-440
• Prices: $215.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Purity: >90%
• Description: proTAME is a cell-permeable prodrug capable of inducing mitotic arrest and cell death in HeLa and other cell types. proTAME is converted to its active parent molecule (TAME, tosyl-L-arginine methyl ester) by intracellular esterases. TAME inhibits the ubiquitin ligase activity of the anaphase-promoting complex/cyclosome (APC/C) by preventing its activation by Cdc20 and Cdh1.