| Description |
This fully functional N-terminal FLAG-tagged NEDD8 is a potent, irreversible inhibitor of NEDD8-specific isopeptidases (like NEDP1 or SENP8, Cat # E-800). Useful for inhibiting the hydrolysis of poly-NEDD8 chains on substrate proteins in vitro and thus enhances poly-NEDD8 chain accumulation. The epitope tag is a hydrophilic octapeptide (DYKDDDDK) derived from the sequence of the bacteriophage 7 gene-10 product. This epitope allows for the sensitive identification or purification of NEDD8 deconjugating activities since it is specifically recognized by anti-FLAG antibodies M1, M2 or M5.
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